Abstract #0457

Motion Compensation in Pulmonary Ultra-short Echo Time MRI: Preliminary results in Idiopathic Pulmonary Fibrosis

Luis A Torres¹, Xucheng Zhu^2,3, Nathan Sandbo⁴, Mark L Shiebler^4,5, Peder Larson^2,3, and Sean B Fain^1,5,6

¹Dept. of Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Dept. of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, ³UCSF/UC Berkeley Graduate Program in Bioengineering, University of California - San Francisco, San Francisco, CA, United States, ⁴Dept. of Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁵Dept. of Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁶Dept. of Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States

Acquiring pulmonary MRI images without motion corruption is a challenging task. In this work, we evaluate several conventional and advanced retrospective motion compensation techniques in subjects with idiopathic pulmonary fibrosis (IPF). We evaluate the effectiveness of each technique using concomitantly acquired CT scans, contrast to noise, and sharpness measures. We find that registration-based techniques show a significant improvement in CNR and sharpness. We also observe significantly improved image quality when referenced side-by-side with CT. We conclude that registration-based techniques could be used to better resolve subtle fibrotic textures in IPF.

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