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Abstract #0479

31P-MRSI of the human heart in 2 ½ minutes at 7T using concentric rings (CONCEPT)

William T Clarke1, Lukas Hingerl2, Wolfgang Bogner2, Ladislav Valkovic3,4, and Christopher T Rodgers3,5
1Wellcome Centre for Integrative Neuroimaging, NDCN, University of Oxford, Oxford, United Kingdom, 2High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 4Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

A density-weighted concentric ring trajectory MRSI sequence is implemented for cardiac 31P-MRS at 7T. The sequence is characterised in phantoms and in five healthy participants. Quantitative comparisons are made against a previously implemented acquisition weighted CSI sequence with matched acquisition time and voxel size. The proposed sequence (CONCEPT) was found to robustly measure 3D localised PCr/ATP ratios of the human myocardium 2.59 times faster or with 1.73 times smaller nominal volume than standard acquisition weighted CSI.

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