Abstract #0479

31P-MRSI of the human heart in 2 ½ minutes at 7T using concentric rings (CONCEPT)

William T Clarke¹, Lukas Hingerl², Wolfgang Bogner², Ladislav Valkovic^3,4, and Christopher T Rodgers^3,5

¹Wellcome Centre for Integrative Neuroimaging, NDCN, University of Oxford, Oxford, United Kingdom, ²High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁵Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

A density-weighted concentric ring trajectory MRSI sequence is implemented for cardiac ³¹P-MRS at 7T. The sequence is characterised in phantoms and in five healthy participants. Quantitative comparisons are made against a previously implemented acquisition weighted CSI sequence with matched acquisition time and voxel size. The proposed sequence (CONCEPT) was found to robustly measure 3D localised PCr/ATP ratios of the human myocardium 2.59 times faster or with 1.73 times smaller nominal volume than standard acquisition weighted CSI.

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