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Abstract #0503

CEST and qMT Properties of Brain Metastases from Radio-resistant and Radio-sensitive Primary Tumours

Hatef Mehrabian1, Wilfred W Lam1, Hany Soliman1,2,3, Sten Myrehaug2,3, Arjun Sahgal1,2,3, and Greg J Stanisz1,4
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Radiation Oncology, University of Toronto, Toronto, ON, Canada, 4Medical Biophysics, University of Toronto, Toronto, ON, Canada

Previous animal studies have shown differences in CEST properties of radio-resistant and radio-sensitive renal cell carcinoma xenografts. The current study probed the differences in CEST and MT properties of brain metastases from radio-resistant and radio-sensitive primary tumours. We observed significantly lower amount of magnetization transfer, RM0B/RA, and direct water saturation effect, 1/(RAT2A) in brain metastases from radio-resistant tumours compared to those from radio-sensitive tumours. However, the CEST effects of the two cohorts were not different. Such information should be considered when investigating brain metastases and their response to treatment.

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