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Abstract #0505

Unveiling the fate of glycolytic substrates using multi-spectral CEST: proof of concept with 2DG in the rat brain

Yohann Mathieu-Daudé1,2, Mélissa Vincent1,2, Julien Valette1,2, and Julien Flament1,2
1Molecular Imaging Research Center (MIRCen), Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Fontenay-aux-Roses, France, 2UMR 9199, Neurodegenerative Diseases Laboratory, Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay, Fontenay-aux-Roses, France

2-Deoxy-D-glucose (2DG), an analogue of glucose similarly transported but with metabolism blocked after the first phosphorylation into 2DG-6-phosphate (2DG6P), has already been used to study glycolytic metabolism using gluCEST. However, origin of glucoCEST signal is still an open question important to be addressed. In this study, we measured for the first time variations of CEST signal in the rat brain at different resonance frequencies following 2DG injection. The richness of CEST signal can help assessing the fate of glycolytic substrates and would constitute a first step toward quantitative measurement of glucose metabolism using CEST method.

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