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Abstract #0508

Towards clinical CEST-MRF: whole brain snapshot CEST MR Fingerprinting at 3T using spin-lock saturation and a centric 3D-EPI readout

Kai Herz1, Sebastian Mueller1, Or Perlman2, Ruediger Stirnberg3, Tony Stoecker3,4, Klaus Scheffler1,5, Christian Farrar2, and Moritz Zaiss1,6
1Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 4Department of Physics and Astronomy, University of Bonn, Bonn, Germany, 5Department of Biomedical Magnetic Resonance, Eberhard Karls University Tuebingen, Tuebingen, Germany, 6Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany

Quantitative CEST imaging is still not applied in clinical routine, as both quantification and whole brain coverage require usually long scan times. In this work, we present a CEST-MRF protocol using spin-lock saturation pulses and a fast 3D-EPI readout with whole brain coverage. This enables a fast generation of quantitative amide proton concentration maps of the entire brain at a clinical scanner.

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