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Abstract #0511

Transient-State Inhomogeneous Magnetisation Transfer: Towards Magnetisation Transfer Fingerprinting

Daniel J. West1, Gastao Cruz1, Olivier Jaubert1, Rui P. A. G. Teixeira1,2, Torben Schneider3, Jacques-Donald Tournier1,2, Jo Hajnal1,2, Claudia Prieto1, and Shaihan J. Malik1,2
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Centre for The Developing Brain, King's College London, London, United Kingdom, 3Philips Healthcare, Guildford, United Kingdom

Inhomogeneous magnetisation transfer (ihMT) is a contrast mechanism that has shown high specificity towards myelinated tissue. Contrast is typically generated using sequences comprising a preparation phase with several RF saturation pulses, followed by multiple readout periods for measurement. Here, we present a transient acquisition scheme that alternates between periods of multi-band and single-band RF pulses, to efficiently generate ihMT contrast during a single data acquisition. Since signal is transiently varying throughout, we use a dictionary-based low-rank inversion reconstruction method originally proposed for magnetic resonance fingerprinting. Simulation, phantom and human in-vivo experiments are included.

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