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Abstract #0513

Fat fraction mapping using bSSFP Signal Profile Asymmetries for Robust multi-Compartment Quantification (SPARCQ)

Giulia MC Rossi1,2, Tom Hilbert1,2,3, Adèle LC Mackowiak1,2, Katarzyna Pierzchała4,5, Tobias Kober1,2,3, and Jessica AM Bastiaansen1
1Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 2Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 3LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

A novel quantitative framework for detection of different tissue compartments based on bSSFP signal profile asymmetries (SPARCQ) is reported. SPARCQ uses a dictionary-based weight optimization algorithm to estimate voxel-wise off-resonance frequency and relaxation time ratio spectra from acquired bSSFP signal profiles. From the obtained spectra, quantitative parameters (i.e. fractions of the components of interest, thermal equilibrium magnetization) can be extracted. Validation and proof-of-concept are provided for voxel-wise water-fat separation and fat fraction mapping. Accuracy and repeatability of SPARCQ are demonstrated with phantom and in vivo experiments.

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