Abstract #0525

In vivo irreversible and reversible transverse relaxation rates in human cerebral cortex via line scans at 7T with 250 micron radial resolution

Mukund Balasubramanian^1,2, Robert V. Mulkern^1,2, and Jonathan R. Polimeni^1,3,4

¹Harvard Medical School, Boston, MA, United States, ²Department of Radiology, Boston Children's Hospital, Boston, MA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

A novel “line-scan GESSE” pulse sequence was used to measure irreversible and reversible transverse relaxation rates—R₂ and R₂´, respectively—in the cerebral cortex of eight healthy human subjects, scanned at 7T with extremely high resolution (250 μm) in the radial direction, i.e., perpendicular to the cortical surface. Within primary visual (V1), motor (M1) and somatosensory (S1) cortex, we observed patterns of R₂ versus cortical depth that were quite consistent across subjects. These patterns are also consistent with the intracortical non-heme iron content in these areas, known from prior histology studies.

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