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Abstract #0551

Calculation of Concentration of Contrast Media, Relaxivity, Extracellular pH and Oxygen Extraction Fraction for Brain Tumor Characterization 

Yuki Matsumoto1, Masafumi Harada1, Yuki Kanazawa1, Takashi Abe1, Maki Otomo1, Yo Taniguchi2, Masaharu Ono3, and Yoshitaka Bito3
1Tokushima University, Tokushima, Japan, 2Research & Development Group, Hitachi, Ltd., Tokyo, Japan, 3Healthcare Business Unit, Hitachi, Ltd., Tokyo, Japan

Concentration of contrast agent (CM), relaxivity (r1), extracellular pH (pHe), and oxygen extraction fraction (OEF), maps were calculated for detecting changes in tissue environment of brain diseases. As a result, the pHe value on glioblastoma or brain metastasis region was significantly lower than that on radiation necrosis (see Fig.3; P < 0.001). The OEF value on glioblastoma region recorded significantly lower values than radiation necrosis and lung metastasis (P < 0.001) while there was no significant difference amongst glioblastoma, breast metastasis, and lung metastasis (P > 0.05).

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