Functional magnetic resonance imaging (fMRI) localizes active regions of the brain during brain stimuli. In this work, we demonstrate hyperpolarized (HP) 129Xe fMRI in two classical fMRI experiments: a flashing visual stimulus and a fist-clenching motor stimulus. Using a chemical shift saturation recovery (CSSR) pulse sequence, our processed images localize brain activity to regions of the brain correlated to those identified using conventional Blood Oxygenation Level Dependent fMRI. The sensitivity of Xe fMRI was nearly two orders of magnitude greater than that of BOLD fMRI. In addition, 129Xe fMRI allows presenting stimuli with significantly smaller repetition frequencies.
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