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Abstract #0562

3D amplified MRI (aMRI) for visualizing pulsatile brain motion

Itamar Terem*1, Leo Dang*2, Allen Champagne3, Javid Abderezaei 4, Zainab Almadan 2, Anna-Maria Lydon 5, Mehmet Kurt4,6, Miriam Scadeng2,7,8, and Samantha J Holdsworth2,8
1Department of Electrical Engineering & Department of Structural Biology, Stanford University, Stanford, CA, United States, 2Department of Anatomy and Medical Imaging & Centre for Brain Research, University of Auckland, Auckland, New Zealand, 3Centre for Neuroscience Studies, Queen’s University, Kingston, ON, Canada, 4Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ, United States, 5Centre for Advanced MRI, University of Auckland, Auckland, New Zealand, 6Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 7Department of Radiology, University of California, San Diego, CA, United States, 8Mātai Medical Research Institute, Gisborne-Tairāwhiti, New Zealand

Amplified Magnetic Resonance Imaging (aMRI) has been introduced as a new brain motion detection and visualization method. Originally employed to amplify pulsatile brain motion in 2D, aMRI has shown to be promising for differentiating abnormal from normal pulsatile brain motion in obstructive brain disorders. Here, we further improve aMRI with the introduction of a combined 3D aMRI acquisition and post-processing tool, with subsequent image processing with optical flow and strain mapping. The 3D aMRI tool is then tested on both multi-slice and volumetric data and its ability to capture 3D brain motion is analyzed.

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