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Abstract #0565

Fast Quantitative Multiparametric Mapping using 3D-EPI with Segmented CAIPIRINHA Sampling at 3T

Difei Wang1, Tony Stöcker1,2, and Rüdiger Stirnberg1
1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2Department of Physics and Astronomy, University of Bonn, Bonn, Germany

By comparison to a gold standard multiparametric mapping (MPM) protocol at 3T, this study shows that multi-echo 3D-EPI with highly segmented CAIPIRINHA sampling can yield whole-head T1, PD*, MTsat and R2* maps of high quality at 1mm isotropic resolution in less than 3 minutes scan time. Even less than 1 minute of single-echo 3D-EPI is sufficient to yield accurate quantitative T1, PD* and MTsat maps. If necessary, SNR can be improved by including repeated EPI measurements. Optional motion- and distortion-correction across measurements may further improve results. Motion-robust MPM thus renders assessing quantitative parameter maps in clinical or population studies feasible.

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