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Abstract #0571

Quantitative Evaluation of Tumor-related Vessels on Ultrafast Dynamic Contrast-enhanced MRI: Image Biomarker of Breast Cancer Proliferation

Kango Kawase1, Masako Y Kataoka2, Tomohiro Takemura1, Takuto Fukutome1, Kojiro Yano3, Maya Honda2, Mami Iima2, Dominik Marcel Nickel4, Tatsuki Kataoka5, Masakazu Toi6, and Kaori Togashi2
1Faculty of Medicine, Kyoto University, Kyoto, Japan, 2Department of Diagnostic Imaging and Nuclear Medicine,, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Osaka Institute of Technology, Osaka, Japan, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 6Department of Breast Surgery, Kyoto University, Kyoto, Japan

For quantitative evaluation of tumor-related vessels, convolution filter processing was applied to ultrafast dynamic contrast-enhanced (UF-DCE) MRI of 51 lesions to obtain vessel length and crossing count as quantitative markers. The current analysis showed that these imaging markers were associated with a subtype of invasive breast cancer, the Ki-67 index, among invasive breast cancers. This opens a new approach to the evaluation of tumor-related vessels and tumor microenvironment.

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