Abstract #0603

dSAGE enables distortion-free diffusion, spin and gradient echo imaging in 1 minute

Zijing Zhang^1,2, Congyu Liao², Jaejin Cho², Mary Kate Manhard², Wei-Ching Lo³, Jinmin Xu^1,2, Kawin Setsomepop^2,4,5, Huafeng Liu¹, and Berkin Bilgic^2,4

¹State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, ²Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts general hospital, Charlestown, MA, United States, ³Siemens Medical Solutions, Boston, MA, United States, ⁴Harvard Medical School, Boston, MA, United States, ⁵Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

We propose dSAGE, a new EPI sequence for diffusion, Spin- and Gradient-echo imaging. We exploit unused sequence time during the b=0 acquisition in a diffusion experiment to collect additional T2*- and T2'-weighted contrasts with high in-plane resolution for free. We use a multi-shot acquisition with high in-plane acceleration to achieve 1x1 mm2 resolution, and alternate the phase-encoding polarities across the shots to eliminate geometric distortion using the navigator-free Blip Up-Down Acquisition(BUDA) technique(1). We demonstrate the ability of BUDA-dSAGE to provide whole-brain, distortion-free, high-SNR images with T2*-, T2'-, T2-weighted contrasts and 3-direction dMRI and apparent diffusion coefficient (ADC) maps in 1-minute.

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