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Abstract #0603

dSAGE enables distortion-free diffusion, spin and gradient echo imaging in 1 minute

Zijing Zhang1,2, Congyu Liao2, Jaejin Cho2, Mary Kate Manhard2, Wei-Ching Lo3, Jinmin Xu1,2, Kawin Setsomepop2,4,5, Huafeng Liu1, and Berkin Bilgic2,4
1State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, 2Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts general hospital, Charlestown, MA, United States, 3Siemens Medical Solutions, Boston, MA, United States, 4Harvard Medical School, Boston, MA, United States, 5Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

We propose dSAGE, a new EPI sequence for diffusion, Spin- and Gradient-echo imaging. We exploit unused sequence time during the b=0 acquisition in a diffusion experiment to collect additional T2*- and T2'-weighted contrasts with high in-plane resolution for free. We use a multi-shot acquisition with high in-plane acceleration to achieve 1x1 mm2 resolution, and alternate the phase-encoding polarities across the shots to eliminate geometric distortion using the navigator-free Blip Up-Down Acquisition(BUDA) technique(1). We demonstrate the ability of BUDA-dSAGE to provide whole-brain, distortion-free, high-SNR images with T2*-, T2'-, T2-weighted contrasts and 3-direction dMRI and apparent diffusion coefficient (ADC) maps in 1-minute.

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