Wave-CAIPI is a parallel imaging technique that can provide high accelerations with negligible g-factor and artifact penalties. However, gradient amplitude & slew rate limits impose a limitation on the amount of wave-encoding and hence the acceleration capability of this technique. In this study, we propose a multi-frequency wave-encoding method (mf-wave) that uses both the gradients and a combined RF and B0 shim array (32-channel) to perform wave-encoding simultaneously and synergistically at different wave frequencies during the acquisition. We demonstrate that mf-wave can enable ~20-fold acceleration with an acceptable g-factor noise penalty at 3T in vivo.
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