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Abstract #0637

MRI-assisted high temporal resolution dynamic FDG-PET imaging for assessing brain functions

Viswanath Pamulakanty Sudarshan1,2,3, Shenpeng Li4, Anthony Fernandez1, Phillip Ward4,5, Sharna Jamadar4,5, Gary Egan4,5, Suyash Awate3, and Zhaolin Chen4
1Monash University, Clayton, Australia, 2IITB Monash Research Academy, Mumbai, India, 3Indian Institute of Technology, Bombay, Mumbai, India, 4Monash Biomedical Imaging, Clayton, Australia, 5Turner Institute for Brain and Mental Health, Clayton, Australia

Simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) provide complementary structural and functional information. Recent developments in continuous infusion functional PET (fPET) have shown promising results to track dynamic changes in brain metabolism. Although fPET provides opportunities to investigate functional metabolism in the brain, the temporal resolution still remains a major challenge compared to functional MRI (fMRI). In this work, we use anatomical MRI information modeled as a Bowsher prior to improve the sensitivity of fPET at higher temporal resolution. We validate our MRI-assisted fPET analysis framework using both in-silico and in-vivo experiments.

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