Abstract #0707

Towards In Vivo Prostate Microstructure Mapping Using Diffusion-Relaxation Correlation Spectrum Imaging

Zhaohuan Zhang^1,2 and Holden Wu^1,2

¹Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

Recent work has demonstrated the ability of Diffusion-Relaxation Correlation Spectrum Imaging (DR-CSI) to quantify prostate microscopic tissue compartments (epithelium, stroma and lumen) in ex vivo prostate specimens at 3T using whole-mount digital histopathology as the reference. This study further developed DR-CSI for in vivo characterization of prostate microstructure using high resolution ex vivo DR-CSI as the reference. Consistent trends in DR-CSI signal component fraction variations in different prostate regions were found using in vivo DR-CSI across subjects, and agreed with trends on ex vivo DR-CSI.

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