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Abstract #0707

Towards In Vivo Prostate Microstructure Mapping Using Diffusion-Relaxation Correlation Spectrum Imaging

Zhaohuan Zhang1,2 and Holden Wu1,2
1Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

Recent work has demonstrated the ability of Diffusion-Relaxation Correlation Spectrum Imaging (DR-CSI) to quantify prostate microscopic tissue compartments (epithelium, stroma and lumen) in ex vivo prostate specimens at 3T using whole-mount digital histopathology as the reference. This study further developed DR-CSI for in vivo characterization of prostate microstructure using high resolution ex vivo DR-CSI as the reference. Consistent trends in DR-CSI signal component fraction variations in different prostate regions were found using in vivo DR-CSI across subjects, and agreed with trends on ex vivo DR-CSI.

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