In-vivo microstructure imaging in cortical grey matter is limited by low imaging resolution and signal contamination from CSF. In this work, we use FLAIR to eliminate free water signal in the brain, and thus enhance sensitivity to microscopic tissue architecture in the cortex. We present the advantage of CSF suppression in Neural Soma Imaging, a state-of-the-art diffusion technique that focuses on the salient features of grey matter. We show high-resolution maps (1.5 mm isotropic) of neural tissue microstructure and T1- and T2-relaxation times, and demonstrate that neural projection density estimates are significantly higher when the CSF signal is eliminated.
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