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Abstract #0724

Validation and application of soma and neurite density imaging (SANDI) for in-vivo human brainstem nuclei atlasing

Marta Bianciardi1, Maria G. GarcĂ­a-Gomar1, Kavita Singh1, Michele Guerreri2, Alejandra Sierra3, Jussi Tohka3, Ali Abdollahzadeh3, Hui Zhang2, and Marco Palombo2
1Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, MA, United States, 2Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 3A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

Despite the development of detailed in-vivo human cortical atlases, in-vivo brainstem nuclei atlasing is still at its early stages due to reduced gray-white matter MRI-contrast in the brainstem compared to the cortex. Recently, we generated an in-vivo probabilistic atlas of 16 human brainstem nuclei based on multi-contrast 7Tesla MRI. Nevertheless, to further expand the in-vivo brainstem nuclei atlas, there is an unmet need from additional MRI-contrast reflecting brainstem cytoarchitecture. We found that recently developed in-vivo Soma-And-Neurite-Density-Imaging (SANDI) provides original MRI-contrast directly related to ex-vivo brainstem nuclei cytoarchitecture, and can be used to expand the current in-vivo human brainstem nuclei atlas.

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