Despite the development of detailed in-vivo human cortical atlases, in-vivo brainstem nuclei atlasing is still at its early stages due to reduced gray-white matter MRI-contrast in the brainstem compared to the cortex. Recently, we generated an in-vivo probabilistic atlas of 16 human brainstem nuclei based on multi-contrast 7Tesla MRI. Nevertheless, to further expand the in-vivo brainstem nuclei atlas, there is an unmet need from additional MRI-contrast reflecting brainstem cytoarchitecture. We found that recently developed in-vivo Soma-And-Neurite-Density-Imaging (SANDI) provides original MRI-contrast directly related to ex-vivo brainstem nuclei cytoarchitecture, and can be used to expand the current in-vivo human brainstem nuclei atlas.
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