Abstract #0729

Using glutamate-CEST to characterize water diffusion inside neurons: initial results

Mélissa Vincent^1,2, Yohann Mathieu-Daudé^1,2, Julien Flament^1,2, and Julien Valette^1,2

¹Molecular Imaging Research Center (MIRCen), Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Fontenay-aux-Roses, France, ²UMR 9199, Neurodegenerative Diseases Laboratory, Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay, Fontenay-aux-Roses, France

It is still unclear how diffusion properties of water differ from one compartment to another (neurons, glial cells, extracellular space…). Here we propose the idea that Chemical Exchange Saturation Transfer of Glutamate (gluCEST) may be used to specifically reduce the contribution of intraneural water to the overall signal attenuation, thus providing enhanced sensitivity to non-neuronal compartments. Acquisitions performed in two rats yields water ADC slightly but significantly higher when gluCEST is performed, supporting the idea that water diffusion is slower inside neurons.

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