A convolutional neural network based tag tracking method for cardiac grid-tagged data was developed and validated. An extensive synthetic data simulator was created to generate large amounts of training data from natural images with analytically known ground-truth motion. The method was validated using both a digital cardiac deforming phantom and tested using in vivo data. Very good agreement was seen in tag locations (<1.0mm) and calculated strain measures (<0.02 midwall Ecc)
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