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Abstract #0842

A Pilot Evaluation of Amide Proton Transfer-Weighted (APTw) MR Imaging in Characteristics and Diagnosis of Premenopausal Breast Tumors

Nan Zhang1, Qingwei Song1, Lina Zhang1, Ailian Liu1, Haonan Zhang1, Yu Song1, Liangjie Lin2, Jiazheng Wang2, and Zhiwei Shen2
1The First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Philips Healthcare, Beijing, China

Amide proton transfer (APT) imaging is based on the chemical exchange between free bulk water protons and the amide protons (-NH) of endogenous mobile proteins and peptides in tissue. Previous studies have shown that APT-weighted (APTw) MRI could noninvasively identify and differentiate tumors in brain, head and neck etc. This study aims to explore the feasibility of APTw-MRI in characteristics and discrimination of premenopausal malignant and benign breast tumors.The results show that the APTw MR imaging efficiency of diagnosis of premenopausal breast tumors were 0.904.

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