Abstract #0842

A Pilot Evaluation of Amide Proton Transfer-Weighted (APTw) MR Imaging in Characteristics and Diagnosis of Premenopausal Breast Tumors

Nan Zhang¹, Qingwei Song¹, Lina Zhang¹, Ailian Liu¹, Haonan Zhang¹, Yu Song¹, Liangjie Lin², Jiazheng Wang², and Zhiwei Shen²

¹The First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Philips Healthcare, Beijing, China

Amide proton transfer (APT) imaging is based on the chemical exchange between free bulk water protons and the amide protons (-NH) of endogenous mobile proteins and peptides in tissue. Previous studies have shown that APT-weighted (APTw) MRI could noninvasively identify and differentiate tumors in brain, head and neck etc. This study aims to explore the feasibility of APTw-MRI in characteristics and discrimination of premenopausal malignant and benign breast tumors.The results show that the APTw MR imaging efficiency of diagnosis of premenopausal breast tumors were 0.904.

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