Amide proton transfer (APT) imaging is based on the chemical exchange between free bulk water protons and the amide protons (-NH) of endogenous mobile proteins and peptides in tissue. Previous studies have shown that APT-weighted (APTw) MRI could noninvasively identify and differentiate tumors in brain, head and neck etc. This study aims to explore the feasibility of APTw-MRI in characteristics and discrimination of premenopausal malignant and benign breast tumors.The results show that the APTw MR imaging efficiency of diagnosis of premenopausal breast tumors were 0.904.