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Abstract #0849

The IronTract challenge: Validation and optimal tractography methods for the HCP diffusion acquisition scheme

Chiara Maffei1, Gabriel Girard2,3, Kurt G. Schilling4, Nagesh Adluru5, Dogu Baran Aydogan6, Andac Hamamci7, Fang-Cheng Yeh8, Matteo Mancini9,10, Ye Wu11, Alessia Sarica12, Achille Teillac13,14,15, Steven H. Baete16,17, Davood Karimi18, Ying-Chia Lin16,17, Fernando Boada16,17, Nathalie Richard13, Bassem Hiba13, Aldo Quattrone12, Yoonmi Hong11, Dinggang Shen11, Pew-Thian Yap11, Tommy Boshkovski10, Jennifer S. W. Campbell19, Nikola Stikov10, G. Bruce Pike20, Barbara B. Bendlin5, Andrew L. Alexander5, Vivek Prabhakaran5, Adam Anderson21, Bennett A. Landman4,21, Erick J.Z. Canales-Rodrígue3,22,23, Muhamed Barakovic3,24, Jonathan Rafael-Patino3, Thomas Yu3, Gaëtan Rensonnet3,25, Simona Schiavi3,26, Alessandro Daducci26, Marco Pizzolato3, Elda Fischi-Gomez3,24, Jean-Philippe Thiran2,3, George Dai27, Giorgia Grisot28, Nikola Lazovski29, Albert Puente29, Matt Rowe29, Irina Sanchez29, Vesna Prchkovska29, Robert Jones1, Julia Lehman30, Suzanne Haber30, and Anastasia Yendiki1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Radiology Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland, 3Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 4Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 5University of Wisconsin, Madison, WI, United States, 6Department of Neuroscience and Biomedical Engineering, Aalto University, Helsinki, Finland, 7Department of Biomedical Engineering, Faculty of Engineering, Yeditepe University, Instanbul, Turkey, 8Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States, 9Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom, 10NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada, 11Department of Radiology and BRIC, University of North Carolina, Chapel Hill, NC, United States, 12Neuroscience Research Center, University Magna Graecia of Catanzaro, Catanzaro, Italy, 13CNRS/ISC, Bron, France, 14Université de Bordeaux, Bordeaux, France, 15CNRS/INCIA, Bordeaux, France, 16Center for Advanced Imaging Innovation and Research (CAI2 R), NYU School of Medicine, New York, NY, United States, 17Center for Biomedical Imaging, Dept. of Radiology, NYU School of Medicine, New York, NY, United States, 18Boston Children's Hospital, Boston, MA, United States, 19Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 20Hotchkiss Brain Institute and Department of Radiology, University of Calgary, Calgary, AB, Canada, 21Department of Electrical Engineering, Vanderbilt University, Nashville, TN, United States, 22FIDMAG Germanes Hospitalàries, Sant Boi de Llobregat, Barcelona, Spain, 23Mental Health Research Networking Center (CIBERSAM), Madrid, Spain, 24Translational Imaging in Neurology (ThINK), Department of Medicine and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland, 25ICTEAM Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium, 26Computer Science Department, University of Verona, Verona, Italy, 27Wellesley College, Wellesley, Wellesley, MA, United States, 28DeepHealth, Inc., Cambridge, MA, United States, 29QMENTA, Inc., Barcelona, Spain, 30Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY, United States

We present results from IronTract, the first challenge to evaluate tractography on the two-shell diffusion scheme of the Human Connectome Project (HCP). Accuracy was evaluated by comparison to tracer injections in the same macaque brains as the diffusion data. Training and validation datasets involved different injection sites. We observed that optimizing data analysis with respect to one injection site does not guarantee optimality for another; encouragingly, two teams could achieve consistently high performance in both datasets. We also found that, when analysis methods are optimized, the HCP scheme may achieve similar accuracy as a more demanding diffusion spectrum imaging acquisition.

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