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Abstract #0862

Grading bladder urothelial carcinoma using a non-Gaussian fractional order calculus diffusion model

Cui Feng1,2, Yanchun Wang1, Guangyu Dan2,3, Zheng Zhong2,3, M. Muge Karaman2,3, Daoyu Hu1, and Xiaohong Joe Zhou2,3,4,5
1Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, 3Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 4Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, 5Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States

Diffusion-weighted imaging based on apparent diffusion coefficient (ADC) has been used for bladder urothelial carcinoma grading. However, a considerable overlap between the low- and high-grade bladder urothelial carcinoma has hindered its clinical acceptance. We employed high b-value diffusion imaging with a non-Gaussian fractional-order calculus (FROC) diffusion model for grading bladder urothelial carcinoma. Significant differences were observed in the FROC parameters D, β and μ, between the low- and high-grade urothelial carcinoma. The combination of the FROC parameters provided substantially better performance than ADC. These findings indicate a promising role of FROC parameters for characterizing bladder urothelial carcinoma and beyond.

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