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Abstract #0866

Contribution of parenchymal water and CSF-like water to changes in brain water diffusivity in post-natal development and aging

Laura D. Reyes1, Amritha Nayak1,2, Alzheimer’s Disease Neuroimaging Initiative *3, and Carlo Pierpaoli1
1NIBIB, National Institutes of Health, Bethesda, MD, United States, 2Henry M. Jackson Foundation, Bethesda, MD, United States, 3Alzheimer’s Disease Neuroimaging Initiative, Los Angeles, CA, United States

In this study, we used a biexponential dual compartment diffusion tensor imaging (DTI) model to characterize different pools of parenchymal water to investigate CSF-like free water and parenchymal diffusivity in childhood, early adulthood, and elderly adulthood, and examine how they change across the lifespan. We identified age-related changes in the contribution of parenchymal and CSF-like free water to age-related changes in overall diffusivity that can be linked to changes in tissue microstructure.

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