Abstract #0866

Contribution of parenchymal water and CSF-like water to changes in brain water diffusivity in post-natal development and aging

Laura D. Reyes¹, Amritha Nayak^1,2, Alzheimer’s Disease Neuroimaging Initiative *³, and Carlo Pierpaoli¹

¹NIBIB, National Institutes of Health, Bethesda, MD, United States, ²Henry M. Jackson Foundation, Bethesda, MD, United States, ³Alzheimer’s Disease Neuroimaging Initiative, Los Angeles, CA, United States

In this study, we used a biexponential dual compartment diffusion tensor imaging (DTI) model to characterize different pools of parenchymal water to investigate CSF-like free water and parenchymal diffusivity in childhood, early adulthood, and elderly adulthood, and examine how they change across the lifespan. We identified age-related changes in the contribution of parenchymal and CSF-like free water to age-related changes in overall diffusivity that can be linked to changes in tissue microstructure.

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