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Abstract #0903

Investigating cerebral energetics and neurotransmission using in vivo 1H MRS and [6,6′-2H2]glucose in a preclinical model

Puneet Bagga1, Laurie J Rich1, Neil E Wilson1, Mark Elliott1, Mitch D Schnall1, Mohammad Haris2,3, John A Detre4, and Ravinder Reddy1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Sidra Medicine, Doha, Qatar, 3LARC, Qatar University, Doha, Qatar, 4Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Energy metabolism and neurotransmission are two crucial processes affecting almost all aspects of cerebral function and 1H MRS allows the non-invasive detection and quantification of neurochemicals. In this study, we performed 1H MRS in conjuction with the administration of [6,6′-2H2]glucose to measure turnover kinetics of glutamate, glutamine and GABA in rat brain. As 2H is invisible on 1H MRS, the turnover of metabolites leads to a corresponding drop in their 1H MR signal visualized by subtraction of the Post-[6,6′-2H2]glucose administration from the Pre-administration 1H MR spectra. The fractional enrichment data can be fitted to evaluate the rates of cerebral energetics.

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