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Abstract #0905

Oxygen carrier therapy slows infarct growth in large vessel occlusion dog model based on perfusion- and diffusion-weighted MRI analysis

Mohammed Salman Shazeeb1,2, Robert King1,2, Josephine Kolstad1, Christopher Raskett1, Natacha Le Moan3, Jonathan A. Winger3, Lauren Kelly3, Ana Krtolica3, Nils Henninger1, and Matthew Gounis1
1University of Massachusetts Medical School, Worcester, MA, United States, 2Worcester Polytechnic Institute, Worcester, MA, United States, 3Omniox Inc., San Carlos, CA, United States

The dog large vessel occlusion (LVO) model mimics the clinical trend observed in patients where the brain infarct follows either a slow or fast progression. The dog LVO model can be used in the design of new therapeutics to improve clinical outcome in patients. This study examined the effect of an oxygen carrier in its ability to slow infarct growth in the dog LVO model. In fast evolvers, the oxygen carrier therapy prolonged infarct progression and reduced the final normalized infarct volume. Delaying infarct progression can potentially extend the time-window for thrombectomy enabling more patients to receive this critical treatment.

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