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Abstract #0910

Modelling the temporal cascade of abnormalities in diffusion magnetic resonance imaging in sporadic Creutzfeldt-Jakob disease

Riccardo Pascuzzo1, Vikram Venkatraghavan2, Marco Moscatelli1, Marina Grisoli1, Esther E. Bron2, Stefan Klein2, Janis Blevins3, Gianmarco Castelli1, Lawrence B. Schonberger4, Pierluigi Gambetti5, Brian S. Appleby3, and Alberto Bizzi1
1Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, 2Biomedical Imaging Group Rotterdam, Departments of Medical Informatics & Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, 3National Prion Disease Pathology Surveillance Center, Case Western Reserve University, School of Medicine, Cleveland, OH, United States, 4National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States, 5Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, United States

The subtypes of sporadic Creutzfeldt-Jakob disease (sCJD), determined only at autopsy, may have different abnormality patterns in diffusion-weighted magnetic resonance imaging (DW-MRI) according to few reports. For the first time, we provide temporal cascades of the DW-MRI abnormalities in seven distinct sCJD subtypes using a data-driven technique named “discriminative event-based model”. Based on these cascades, we propose a novel procedure to identify the subtype of a patient. We found that sCJD subtypes have either initial cortical (MM/MV1, MM/MV2C, VV1 subtypes) or subcortical involvement (MV2K and VV2) with specific orderings of DW-MRI abnormalities, allowing a correct subtype prediction in most cases.

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