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Abstract #0926

Abnormal static and dynamic functional connectivity in active professional fighters with repetitive head trauma: A resting-state fMRI study

Xiaowei Zhuang1, Virendra Mishra1, Zhengshi Yang1, Karthik Sreenivasan1, Sarah J Banks2, Lauren Bennett3, Bernick Charles1, and Dietmar Cordes1,4
1Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, 2Department of Neuroscience, University of California, San Diego, La Jolla, CA, United States, 3Neuroscience Institute, Hoag Hospital, Irvine, CA, United States, 4University of Colorado, Boulder, Boulder, CO, United States

Both static and dynamic functional connectivity differences between cognitively impaired and non-impaired active professional fighters were first explored. Significant decreased static functional connections and trend-level increased dynamic functional connections among regions involved in memory and executive functions were found in cognitively impaired fighters, which adds brain functional reorganizations to previously observed structural damages in brain deficits related to repetitive head trauma. We further demonstrated that both static and dynamic functional connectivity were sensitive to cognitive declines in this fighter’s cohort, as both static and dynamic functional features can reliably predict cognitive impairment status in fighters.

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