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Abstract #0929

Simultaneous 18F-FDG-PET and 1H-MRSI Metabolic Imaging in Epilepsy Patients: A Feasibility Study

Hui Huang1, Miao Zhang2, Rong Guo3,4, Yudu Li3,4, Yibo Zhao3,4, Jialin Hu1, Hongping Meng2, Xinyun Huang2, Xiaozhu Lin2, Wei Liu5, Biao Li2, Bomin Sun5, Yao Li1, Zhi-Pei Liang3,4, and Jie Luo1
1Institute of Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, 4Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States, 5Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

PET and MRSI could provide metabolic information of the epileptogenic zone, which could add value to presurgical planning of epilepsy patients. This study investigated the feasibility of simultaneous high-resolution MRSI and 18F-FDG-PET for whole brain imaging in epilepsy patients, and studied the correlation between metabolic changes found in MRSI and hypometabolism found in FDG-PET. Our experimental results showed a decrease in NAA and an increase in Cho, concomitant with low FDG uptake.

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