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Abstract #0956

Diffusion phase-imaging using non-linear gradients in anisotropic synthetic fiber phantoms

Pamela Wochner1, Torben Schneider2, Jason Stockmann3, Jack Lee1, and Ralph Sinkus1,4
1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 2Philips Healthare, Guildford, United Kingdom, 3Department of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 4Inserm U1148, LVTS, University Paris Diderot, Paris, France

Diffusion MRI classically uses linear gradients to encode information about micro-structure in the loss of signal magnitude. When replaced by gradients varying quadratically in space, anisotropic diffusion results in a net phase shift, while the signal magnitude is largely preserved. This allows the extraction of information from signal phase inaccessible to other diffusion MRI methods. The phase evolution of anisotropic fiber phantoms were studied in simulations and diffusion experiments. Simulations confirm increasing phase change with increasing anisotropy and mixing time between diffusion gradients. First MR experiments with different mixing times show a phase shift in good agreement with theoretical estimate.

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