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Abstract #0959

Stay on the beat: tuning in on time-dependent diffusion in the heart

Henrik Lundell1, Samo Lasič1,2, Filip Szczepankiewicz3,4,5, Markus Nilsson3, Daniel Topgaard6, Jürgen E. Schneider7, and Irvin Teh7
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Random Walk Imaging AB, Lund, Denmark, 3Clinical Sciences, Lund University, Lund, Sweden, 4Harvard Medical School, Boston, MA, United States, 5Brigham and Women's Hospital, Boston, MA, United States, 6Physical Chemistry, Lund University, Lund, Sweden, 7Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom

Diffusion encoding with general gradient waveforms provides flexibility and experimental efficiency for multidimensional diffusion encoding (MDE). Here we investigate b-tensor shape and spectral content as two independent measurement dimensions for imaging myocardial microstructure. By tuning spectral content, we demonstrate that time-dependent diffusion can be controlled for across b-tensor shapes and that tuning in itself provide a strong image contrast in a clinically feasible setting. For encoding high frequencies alone, our isotropic encoding provides higher experimental efficiency.

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