Diffusion encoding with general gradient waveforms provides flexibility and experimental efficiency for multidimensional diffusion encoding (MDE). Here we investigate b-tensor shape and spectral content as two independent measurement dimensions for imaging myocardial microstructure. By tuning spectral content, we demonstrate that time-dependent diffusion can be controlled for across b-tensor shapes and that tuning in itself provide a strong image contrast in a clinically feasible setting. For encoding high frequencies alone, our isotropic encoding provides higher experimental efficiency.
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