Abstract #0968

SNR-Enhanced High-Resolution Diffusion Imaging Using 3D Simultaneous Multi-Slab (SMSlab) with Root-flipped RF Pulse Design

Simin Liu¹, Erpeng Dai^1,2, and Hua Guo¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²Department of Radiology, Stanford University, Stanford, CA, United States

3D simultaneous multi-slab (SMSlab) is a technique to increase SNR efficiency in high-resolution diffusion imaging. However, it still suffers from the intrinsic low SNR of diffusion MRI, especially when using multi-band RF pulses, which increases the pulse duration and thus lengthens the echo time. In this study, root-flipped RF pulses were used in SMSlab to acquired 1 mm isotropic 3D diffusion images. With a multi-band factor of 2, the root-flipped pulses brought about 12 ms reduction of TE (from 91 to 79 ms), and 16% SNR gain, compared to traditional SINC pulses.

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