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Abstract #0968

SNR-Enhanced High-Resolution Diffusion Imaging Using 3D Simultaneous Multi-Slab (SMSlab) with Root-flipped RF Pulse Design

Simin Liu1, Erpeng Dai1,2, and Hua Guo1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Department of Radiology, Stanford University, Stanford, CA, United States

3D simultaneous multi-slab (SMSlab) is a technique to increase SNR efficiency in high-resolution diffusion imaging. However, it still suffers from the intrinsic low SNR of diffusion MRI, especially when using multi-band RF pulses, which increases the pulse duration and thus lengthens the echo time. In this study, root-flipped RF pulses were used in SMSlab to acquired 1 mm isotropic 3D diffusion images. With a multi-band factor of 2, the root-flipped pulses brought about 12 ms reduction of TE (from 91 to 79 ms), and 16% SNR gain, compared to traditional SINC pulses.

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