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Abstract #0970

Multidimensional correlation MRI of the brain

Kristofor Pas1,2, Michal Komlosh2,3, Daniel Perl4, Peter Basser2, and Dan Benjamini2,3
1University of Texas at Arlington, Arlington, TX, United States, 2National Institutes of Health, Bethesda, MD, United States, 3Uniformed Service University of the Health Sciences, Bethesda, MD, United States, 4Uniformed Services University of the Health Sciences, Bethesda, MD, United States

Multidimensional correlation MRI is an emerging imaging modality that is capable of disentangling highly heterogeneous systems, according to chemical and physical interactions of water within them. Using this approach, the conventional three dimensional MR scalar images are replaced with spatially resolved multidimensional spectra. The ensuing abundance in microstructural and chemical information is a blessing that incorporates a real challenge: how does one distill and refine it into images? Here we introduce a method that robustly identifies the multidimensional spectral components in the image domain, defines the spectral regions of interest, and uses them to reconstruct images of sub-voxel components.

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