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Abstract #0972

Simultaneous Imaging of Diffusion and Coherent Motion in Slow-Flow Compartments in the Brain

Isabelle Heukensfeldt Jansen1, Luca Marinelli1, Ek Tsoon Tan2, Robert Y Shih3,4, J Kevin DeMarco3,4, J Kent Werner3,4, Vincent B Ho3,4, and Thomas Foo1
1GE Global Research Center, Niskayuna, NY, United States, 2Hospital for Special Surgery, New York, NY, United States, 3Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 4Walter Reed National Military Medical Center, Bethesda, MD, United States

We demonstrate a method for simultaneous imaging of diffusion and slow motion in vivo. We use both the magnitude and phase information from image data to reconstruct coherent and incoherent motion (flow and diffusion). We modified a PGSE diffusion imaging sequence so that b-value and encoded velocity can be set independently. We imaged healthy volunteers with a 2-shell sequence with bmax=2000 sec/mm2 and venc=0.24 mm/s at multiple phases during the cardiac cycle using peripheral gating. Results show a distinct periodic motion around the ventricles with RMS speed 0.065 mm/s, moving laterally during systole and medially during diastole

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