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Abstract #0982

High-Resolution 3D Multi-shot Diffusion-Weighted Imaging with Pseudo-Random Sampling and Compressed Sensing

Hing-Chiu Chang1 and Xiaoxi Liu1,2
1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

3D multi-shot diffusion-weighted imaging (msDWI) with multi-slab acquisition can achieve high-resolution diffusion-tensor imaging (DTI), but additional correction is required to eliminate slab boundary artifact associated with multi-slab acquisition. A proposed 3D-MUSER technique can improve the feasible slab thickness by enabling 3D phase correction with a 3D single-shot navigator, thereby making single-slab 3D DTI feasible. However, the relatively long scantime can limit the applications of 3D DTI in neuroscience research, despite high spatial resolution attainable. In this study, we proposed a potential strategy to develop a 3D DTI technique capable of high scan acceleration.

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