Abstract #1007

Reproducibility and Repeatability of Three-dimensional Magnetic Resonance Fingerprinting-based Human Brain Morphometry

Shohei Fujita^1,2, Guido Buonincontri^3,4, Matteo Cencini^3,5, Naoyuki Takei⁶, Rolf F. Schulte⁷, Issei Fukunaga¹, Akifumi Hagiwara¹, Wataru Uchida^1,8, Masaaki Hori⁹, Ryusuke Irie^1,2, Koji Kamagata¹, Osamu Abe², and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, The University of Tokyo, Tokyo, Japan, ³Imago7 Foundation, Pisa, Italy, ⁴IRCCS Stella Maris, Paris, Italy, ⁵Department of Physics, University of Pisa, Pisa, Italy, ⁶MR Applications and Workflow, GE Healthcare, Tokyo, Japan, ⁷GE Healthcare, Munich, Germany, ⁸Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan, ⁹Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Magnetic Resonance fingerprinting (MRF) provides simultaneous acquisition of T1 and T2 values with high reliability. However, the reproducibility and repeatability of human brain morphometry based on MRF still requires investigation. Here, we examined the feasibility of three-dimensional (3-D) MRF to evaluate the brain cortical thickness and volumetric analysis in healthy volunteers. Scan-rescan tests of both 3-D MRF and conventional 3D T1-weighted imaging were performed. For each sequence, the regional cortical thickness and volume of the subcortical structures were measured using automatic brain segmentation software. High agreement between conventional scans and scan-rescan repeatability in healthy human brains were observed.

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