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Abstract #1007

Reproducibility and Repeatability of Three-dimensional Magnetic Resonance Fingerprinting-based Human Brain Morphometry

Shohei Fujita1,2, Guido Buonincontri3,4, Matteo Cencini3,5, Naoyuki Takei6, Rolf F. Schulte7, Issei Fukunaga1, Akifumi Hagiwara1, Wataru Uchida1,8, Masaaki Hori9, Ryusuke Irie1,2, Koji Kamagata1, Osamu Abe2, and Shigeki Aoki1
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Radiology, The University of Tokyo, Tokyo, Japan, 3Imago7 Foundation, Pisa, Italy, 4IRCCS Stella Maris, Paris, Italy, 5Department of Physics, University of Pisa, Pisa, Italy, 6MR Applications and Workflow, GE Healthcare, Tokyo, Japan, 7GE Healthcare, Munich, Germany, 8Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan, 9Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Magnetic Resonance fingerprinting (MRF) provides simultaneous acquisition of T1 and T2 values with high reliability. However, the reproducibility and repeatability of human brain morphometry based on MRF still requires investigation. Here, we examined the feasibility of three-dimensional (3-D) MRF to evaluate the brain cortical thickness and volumetric analysis in healthy volunteers. Scan-rescan tests of both 3-D MRF and conventional 3D T1-weighted imaging were performed. For each sequence, the regional cortical thickness and volume of the subcortical structures were measured using automatic brain segmentation software. High agreement between conventional scans and scan-rescan repeatability in healthy human brains were observed.

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