Abstract #1016

Identification and Correction of Errors in Quantitative Multi-Parameter Mapping (MPM)

Tobias Streubel^1,2, Leonie Klock³, Martina Callaghan⁴, Simone Kühn^3,5, Antoine Lutti⁶, Karsten Tabelow⁷, Nikolaus Weiskopf², Gabriel Ziegler^8,9, and Siawoosh Mohammadi^1,2

¹Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ³Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁴Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, UCL, London, United Kingdom, ⁵Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, ⁶Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne, Switzerland, ⁷Stochastic Algorithms and Nonparametric Statistics, Weierstrass Institute for Applied Analysis and Stochastics, Berlin, Germany, ⁸Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University, Magdeburg, Germany, ⁹German Center for Neurodegenerative Diseases, Magdeburg, Germany

We introduced novel error maps for proton density, longitudinal relaxation and magnetization transfer saturation rates that are more sensitive to artifacts than previously used error measures. We showed that they can be used to identify and down weigh local errors in the quantitative parameter maps for an experiment consisting of two successive multi-parameter mapping (MPM) measurements in a group of 10 healthy subjects.

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