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Abstract #1016

Identification and Correction of Errors in Quantitative Multi-Parameter Mapping (MPM)

Tobias Streubel1,2, Leonie Klock3, Martina Callaghan4, Simone Kühn3,5, Antoine Lutti6, Karsten Tabelow7, Nikolaus Weiskopf2, Gabriel Ziegler8,9, and Siawoosh Mohammadi1,2
1Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 4Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, UCL, London, United Kingdom, 5Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, 6Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne, Switzerland, 7Stochastic Algorithms and Nonparametric Statistics, Weierstrass Institute for Applied Analysis and Stochastics, Berlin, Germany, 8Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University, Magdeburg, Germany, 9German Center for Neurodegenerative Diseases, Magdeburg, Germany

We introduced novel error maps for proton density, longitudinal relaxation and magnetization transfer saturation rates that are more sensitive to artifacts than previously used error measures. We showed that they can be used to identify and down weigh local errors in the quantitative parameter maps for an experiment consisting of two successive multi-parameter mapping (MPM) measurements in a group of 10 healthy subjects.

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