Stroke onset time is a prerequisite for thrombolytic treatment but is unknown in ~25% of acute ischemic stroke patients. A fluid-attenuated inversion recovery (FLAIR)-based MRI index (e.g., DWI-FLAIR mismatch) has been suggested as a surrogate to determine whether the stroke duration is within the treatment window. In this work, we showed that the time when a positive FLAIR contrast appears between ischemic and normal tissue increases with B0, and is dependent on the imaging parameters. Therefore, FLAIR-based studies of stroke onset should be designed or interpreted with care.
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