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Abstract #1055

Determining stroke onset time using T2 relaxation times: A comparison of reference and reference independent methods in ischemic stroke patients

Bryony L. McGarry1, Robin A. Damion1, Terence J. Norton1, Michael J. Knight1, Philip L. Clatworthy2, George W.J. Harston3, Keith W. Muir4, and Risto A. Kauppinen5
1School of Psychological Science, University of Bristol, Bristol, United Kingdom, 2Stroke Neurology, North Bristol NHS Trust, Bristol, United Kingdom, 3Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 4Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom, 5Faculty of Engineering, University of Bristol, Bristol, United Kingdom

Unknown onset time is a common contradiction for anti-thrombolytic treatment of ischemic stroke. T2 relaxation times within the lesion estimate onset time, but accuracy may be affected by dependence on the non-ischemic hemisphere as reference for pre-ischemic values. In hyperacute ischemic stroke patients, we tested a reference-independent approach shown to be an accurate timer in a preclinical stroke model. This involved modelling the T2 distribution within ADC defined lesions to design linear regression models for onset time estimation. The reference-independent approach was accurate in grey matter and for lesions containing grey and white matter, the reference-dependent approach was more accurate.

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