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Abstract #1065

Serial MR Vessel Wall Imaging Reveals Medical Treatment Response of Symptomatic Intracranial Atherosclerotic Plaque

Jiayu Xiao1, Shlee Song1, Konrad Schlick1, Shuang Xia2, Tao Jiang3, Tong Han4, Robert Jackson1, Oana Dumitrascu1, Marcel Maya1, Patrick Lyden1, Debiao Li1,5, Qi Yang6, and Zhaoyang Fan1,5
1Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Tianjin First Central Hospital, Tianjin, China, 3Beijing Chaoyang Hospital, Beijing, China, 4Tianjin Huanhu Hospital, Tianjin, China, 5University of California, Los Angeles, Los Angeles, CA, United States, 6Beijing Xuanwu Hospital, Beijing, China

Ischemic stroke is a leading cause of disability and death, also has a high recurrence rate. Serial magnetic resonance vessel wall imaging (MR-VWI) was used to quantify the morphological changes of intracranial atherosclerotic plaque during the medical treatment of ischemic stroke patients. Changes of quantitative plaque features were compared between patients with different clinical outcomes. Our study showed an increasing trend in most progression patients. Maximum wall thickness, pre-contrast plaque-wall contrast ratio and post-contrast plaque enhancement ratio showed significant decreases in the non-progression group. Quantitative assessment of atherosclerotic lesion-specific responses to medical therapy is clinically feasible with serial MR-VWI.

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