Abstract #1065

Serial MR Vessel Wall Imaging Reveals Medical Treatment Response of Symptomatic Intracranial Atherosclerotic Plaque

Jiayu Xiao¹, Shlee Song¹, Konrad Schlick¹, Shuang Xia², Tao Jiang³, Tong Han⁴, Robert Jackson¹, Oana Dumitrascu¹, Marcel Maya¹, Patrick Lyden¹, Debiao Li^1,5, Qi Yang⁶, and Zhaoyang Fan^1,5

¹Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Tianjin First Central Hospital, Tianjin, China, ³Beijing Chaoyang Hospital, Beijing, China, ⁴Tianjin Huanhu Hospital, Tianjin, China, ⁵University of California, Los Angeles, Los Angeles, CA, United States, ⁶Beijing Xuanwu Hospital, Beijing, China

Ischemic stroke is a leading cause of disability and death, also has a high recurrence rate. Serial magnetic resonance vessel wall imaging (MR-VWI) was used to quantify the morphological changes of intracranial atherosclerotic plaque during the medical treatment of ischemic stroke patients. Changes of quantitative plaque features were compared between patients with different clinical outcomes. Our study showed an increasing trend in most progression patients. Maximum wall thickness, pre-contrast plaque-wall contrast ratio and post-contrast plaque enhancement ratio showed significant decreases in the non-progression group. Quantitative assessment of atherosclerotic lesion-specific responses to medical therapy is clinically feasible with serial MR-VWI.

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