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Abstract #1095

Vessel architectural imaging in the human heart using heartbeat-to-heartbeat GESE-EPI

Maaike van den Boomen1,2, Mary Kate Manhard1,3, Kyrre E. Emblem4, David E. Sosnovik1,5,6, Niek H.J. Prakken2, Christopher Nguyen1,5,6, Kawin Setsompop1,3,7, and Ronald J.H. Borra2,8
1A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Department of Radiology, University Medical Center Groningen, Groningen, Netherlands, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway, 5Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, 6Department of Medicine, Harvard Medical School, Boston, MA, United States, 7Division of Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States, 8Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, Netherlands

Vessel architectural imaging (VAI) is explored in the heart by using a heartbeat-to-heartbeat GESE-EPI sequence upon injection of Gd-DTPA. Cardiac VAI can provide the vascular type, caliber, density and blood volume fraction indices in the myocardium, in line with previous work performed in the brain. Further histological validation of these indices is needed, but our initial results demonstrates the feasibility of this technique to advance cardiovascular research into cardiac microvascular dysfunction.

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