Abstract #1095

Vessel architectural imaging in the human heart using heartbeat-to-heartbeat GESE-EPI

Maaike van den Boomen^1,2, Mary Kate Manhard^1,3, Kyrre E. Emblem⁴, David E. Sosnovik^1,5,6, Niek H.J. Prakken², Christopher Nguyen^1,5,6, Kawin Setsompop^1,3,7, and Ronald J.H. Borra^2,8

¹A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, University Medical Center Groningen, Groningen, Netherlands, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway, ⁵Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, ⁶Department of Medicine, Harvard Medical School, Boston, MA, United States, ⁷Division of Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States, ⁸Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, Netherlands

Vessel architectural imaging (VAI) is explored in the heart by using a heartbeat-to-heartbeat GESE-EPI sequence upon injection of Gd-DTPA. Cardiac VAI can provide the vascular type, caliber, density and blood volume fraction indices in the myocardium, in line with previous work performed in the brain. Further histological validation of these indices is needed, but our initial results demonstrates the feasibility of this technique to advance cardiovascular research into cardiac microvascular dysfunction.

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