The wave-CAIPI technique was applied to aortic 4D flow MRI. Three healthy volunteers were examined and flow parameters as well as hemodynamic flow patterns were derived from the measured data. The acquisitions were retrospectively accelerated and compared to conventional Cartesian 2D-CAIPI sampling. Using wave-CAIPI sampling, the deviations between flow parameters of the 6-fold accelerated scans and the references (2-fold accelerated) could be reduced by up to 47% compared to Cartesian sampling. As a consequence, the acquisition time of aortic 4D flow acquisitions could be decreased to 3.5 minutes with higher precision, concerning the calculated flow parameters and hemodynamic flow patterns.