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Abstract #1101

The role of rapid capillary resistance decreases in the BOLD response assessed through simulations in a realistic vascular network 

Joerg Peter Pfannmoeller1, Louis Gagnon2, Avery Berman1, and Jonathan Polimeni1
1Imaging, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Physics, Engineering Physics and Optics, Laval University, Quebec, QC, Canada

The brain’s physiology may fundamentally limit the achievable spatial and temporal specificity of gradient-echo fMRI. Even if the physiology does not pose such a limitation a better understanding would allow for data analysis techniques that improve the spatial specificity. Microscopy allows for highly detailed investigations of local physiological mechanism and provides a growing knowledge from which fMRI may benefit profoundly. A current challenge is the transition from focal mechanisms to their consequence on the mesoscopic scale of BOLD examinations. In this abstract we present our recent work on this transition using simulations of the BOLD effect.

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