Abstract #1103

Cross species validation of the layer-fMRI VASO contrast mechanism: data comparison against pre-clinical 2D-OIS and CBV-MRI gold standards.

Aneurin J Kennerley¹, Benedikt A Poser², Frida H Torkelsen¹, Rainer Goebel², Amanda Kaas², and Laurentius Huber²

¹Chemistry, University of York, York, United Kingdom, ²Maastricht Brain Imaging Centre, Maastricht University, Maastricht, Netherlands

With recent advances in ultra-high-field MRI hardware and sequence mechanisms, it has become possible to capture CBV-weighted fMRI signal across cortical layers. However, the exact contrast mechanisms of layer-dependent VASO has not been fully validated with gold-standard pre-clinical methods.

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