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Abstract #1103

Cross species validation of the layer-fMRI VASO contrast mechanism: data comparison against pre-clinical 2D-OIS and CBV-MRI gold standards. 

Aneurin J Kennerley1, Benedikt A Poser2, Frida H Torkelsen1, Rainer Goebel2, Amanda Kaas2, and Laurentius Huber2
1Chemistry, University of York, York, United Kingdom, 2Maastricht Brain Imaging Centre, Maastricht University, Maastricht, Netherlands

With recent advances in ultra-high-field MRI hardware and sequence mechanisms, it has become possible to capture CBV-weighted fMRI signal across cortical layers. However, the exact contrast mechanisms of layer-dependent VASO has not been fully validated with gold-standard pre-clinical methods.

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