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Abstract #1118

Metabolic basis of human brain network nodes in resting-states of eyes-closed and eyes-open

Yury Koush1, Robin A. de Graaf1, Peter Herman1, Douglas L. Rothman1, and Fahmeed Hyder1
1Yale University, New Haven, CT, United States

Resting-state fMRI studies are conducted with eyes-closed (EC) or eyes-open (EO) conditions. Given differences in spontaneous activity between EO and EC conditions, metabolic foundations of fMRI-derived networks, specifically activated (e.g., sensory network) and deactivated (e.g., default mode network, DMN) nodes, are poorly understood. We assessed aerobic glycolysis and excitatory-inhibitory balance in healthy volunteers’ visual cortex (VC, a non-DMN node) and posterior cingulate cortex (PCC, a DMN node) using J-edited fMRS and calibrated fMRI. Functional changes between EO and EC conditions are regionally non-specific to aerobic glycolysis and flow-metabolism coupling, but neurovascular coupling in VC depends on EO and EC conditions.

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