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Abstract #1143

Multi-modality in vivo imaging of cortical bone vasculature: Comparison of diabetes patients to healthy controls

Po-hung Wu1, Misung Han1, Roland Krug1, Jing Liu1, Gabby B. Joseph1, Thomas Link1, and Galateia Kazakia1
1Department of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States

Type 2 diabetes is known to increase fracture risk, possibly through the development of pathological cortical bone porosity. However, the mechanisms of pathological pore growth are not understood. We hypothesize that T2D patients will display altered vascularization within cortical pores due to microvascular disease. In this study, 15 T2D patients and 22 controls were imaged by HR-pQCT and DCE-MRI to analyze vessel and perfusion metrics (eg. vessel density, transition time). The study results suggest that T2D patients have altered vessel distribution and perfusion characteristics, and that microvascular disease may be a factor in diabetic bone disease.

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