Type 2 diabetes is known to increase fracture risk, possibly through the development of pathological cortical bone porosity. However, the mechanisms of pathological pore growth are not understood. We hypothesize that T2D patients will display altered vascularization within cortical pores due to microvascular disease. In this study, 15 T2D patients and 22 controls were imaged by HR-pQCT and DCE-MRI to analyze vessel and perfusion metrics (eg. vessel density, transition time). The study results suggest that T2D patients have altered vessel distribution and perfusion characteristics, and that microvascular disease may be a factor in diabetic bone disease.
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