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Abstract #1145

Quantitative T2, T1ρ, and Diffusion Mapping of Early-Stage Ischemic Osteonecrosis of the Femoral Head: An In Vivo Piglet Model Study at 3T MRI

Casey P. Johnson1,2, Ferenc Toth1, Alexandra R. Armstrong1, Harry K. W. Kim3,4, and Jutta M. Ellermann2,5
1Veterinary Clinical Sciences Department, University of Minnesota, Saint Paul, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Texas Scottish Rite Hospital for Children, Dallas, TX, United States, 4Department of Orthopaedic Surgery, UT Southwestern Medical Center, Dallas, TX, United States, 5Department of Radiology, University of Minnesota, Minneapolis, MN, United States

This study tested whether T2 and T1ρ relaxation times are sensitive in detecting early-stage osteonecrosis of the femoral head in piglet model under in vivo conditions and at clinical 3T MRI. This study builds on recent ex vivo 9.4T studies assessing T2 and T1ρ in the piglet model. We also evaluated apparent diffusion coefficient for comparison. We found that T2, T1ρ, and ADC were all significantly increased in the ischemic vs. contralateral control femoral heads in n=6 piglets one week after onset of ischemia. These methods may be clinically useful to detect and characterize early-stage osteonecrosis to inform treatment decisions.

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