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Abstract #1156

Intervertebral Disc Elastography: Physiological Strain, Stiffness, and Relaxometry in Axial Compression and Bending

Deva D. Chan1,2, Paull C. Gossett2, Robert L. Wilson3, Woong Kim2, Yue Mei4,5,6, Kent Butz2, Nancy Emery7, Eric A. Nauman2, Stéphane Avril6, and Corey P. Neu2,3
1Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, United States, 2Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United States, 4Engineering Mechanics, Dalian University of Technology, Dalian, China, 5International Research Center for Computational Mechanics, Dalian University of Technology, Dalian, China, 6Center for Biomedical and Healthcare Engineering, MINES Saint-Étienne, Saint-Étienne, France, 7Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, United States

IVD degeneration is the most recognized cause of low back pain, characterized by the decline of tissue structure and mechanics. MRI relaxometry is one quantitative measure of IVD degeneration, yet MRI metrics of mechanics have not been fully explored. We quantified patterns of IVD strain and mechanics during physiological compression and bending. Strains patterns depended on the loading mode, and shear modulus in the nucleus pulposus was typically an order of magnitude lower than the annulus fibrosis, except in bending, where the apparent stiffness depended on the loading direction. Strain and material properties provide new possible biomarkers for IVD degeneration.

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