Abstract #1158

About the origin of decreased 1H NMRS-based water T2 in highly fatty infiltrated skeletal muscles of subjects with neuromuscular disorders

Harmen Reyngoudt^1,2, Ericky Caldas de Almeida Araujo^1,2, Pierre-Yves Baudin³, Benjamin Marty^1,2, and Pierre G. Carlier^1,2

¹NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, ²NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, ³Consultants for Research in Imaging and Spectroscopy, Tournai, Belgium

¹H NMRS-based water T₂ (T_2w) has shown to be decreasing when muscle fat fraction levels are elevated (>60%). Here, two myopathy patient groups with similar fat fraction levels (>60%) emerged, being a group with T_2w>30 ms and a group with T_2w<30 ms, which seemed to be correlated to the respective water resonance linewidths. Interpretation of these reduced T_2w values at high fat fractions needs to be handled cautiously. The larger linewidths observed in the spectra characterized by shorter T_2w may be due to the local B₀ gradients induced by susceptibility differences between muscle and fat.

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