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Abstract #1158

About the origin of decreased 1H NMRS-based water T2 in highly fatty infiltrated skeletal muscles of subjects with neuromuscular disorders

Harmen Reyngoudt1,2, Ericky Caldas de Almeida Araujo1,2, Pierre-Yves Baudin3, Benjamin Marty1,2, and Pierre G. Carlier1,2
1NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, 2NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, 3Consultants for Research in Imaging and Spectroscopy, Tournai, Belgium

1H NMRS-based water T2 (T2w) has shown to be decreasing when muscle fat fraction levels are elevated (>60%). Here, two myopathy patient groups with similar fat fraction levels (>60%) emerged, being a group with T2w>30 ms and a group with T2w<30 ms, which seemed to be correlated to the respective water resonance linewidths. Interpretation of these reduced T2w values at high fat fractions needs to be handled cautiously. The larger linewidths observed in the spectra characterized by shorter T2w may be due to the local B0 gradients induced by susceptibility differences between muscle and fat.

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